ECG-guided photoplethysmography (PPG) foundation model pretrained on over 100,000 hours of synchronized PPG-ECG recordings from 58,796 subjects across five clinical and wearable sources, using a CLIP-style contrastive alignment framework so the PPG encoder inherits physiologically grounded structure from paired ECG. Achieves state-of-the-art performance on 13 of 15 conventional physiological-analysis tasks across eight datasets, and shows meaningful discriminative capability (AUC >= 0.70) for 307 ICD-10-coded phenotypes across 16 phecode chapters, including many non-cardiovascular conditions.

ECG foundation model designed to remain accurate when leads are missing or signals are noisy. A 1D ConvNeXt V2 encoder is trained with a dual-mode self-distillation objective (separate lead-missing and noise "teachers") alongside contrastive alignment to detailed diagnostic-criteria text reports retrieved via a lightweight, LLM-free "Cardiac Feature Retrieval" module. Consistently ranks best or second-best across PTB-XL diagnostic tasks and MIT-BIH arrhythmia classification under original, noisy, lead-missing, and combined-corruption conditions. Developed by FPT Software AI Center and the University of Arkansas.

Self-supervised ECG representation learned purely from patient identity: the model is trained so that ECGs from the same patient, recorded at different times, map to nearby points in latent space, with no other labels required. Linear models trained on these representations showed a 51% average performance gain over training from scratch across sex classification, age regression, LVH detection, and AF detection. Developed by the Broad Institute's ML4H group and trained on 3.2 million private ECGs from Massachusetts General Hospital; 12-lead, lead-I-only, and lead-II-only checkpoints are all released.

One of the first open foundation models for PPG signals, pretrained on over 57,000 hours (20 million segments) of publicly available data using a morphology-aware self-supervised objective. Evaluated across 20 tasks from 10 datasets spanning cardiovascular health, sleep disorders, pregnancy monitoring, and general wellbeing. Developed by Nokia Bell Labs and published at ICLR 2025.

Open-source PPG foundation model pretrained directly on real-world, field-collected wearable data rather than clean clinical signals alone, aiming for better generalization to the noise of free-living conditions. Uses a ResNet-based encoder trained with a relative contrastive (RelCon) self-supervised objective, and is directly benchmarked against PaPaGei. Developed at the University of Illinois Urbana-Champaign and published at UbiComp 2025.