Machine-learning surrogate model for estimating pulsatile hemodynamic fields (velocity, pressure) in coronary arteries from a steady-state computational fluid dynamics (CFD) prior, avoiding the high computational cost of full pulsatile CFD. The model, a neural field conditioned on hemodynamic boundary conditions, is discretisation-independent and can be parametrised with message-passing or self-attention layers by relaxing point-wise action to permutation-equivariance. Evaluated on 74 stenotic coronary arteries from coronary CT angiography (CCTA) with patient-specific pulsatile CFD as ground truth, the model produced accurate, discretisation-independent estimates of pulsatile velocity and pressure fields.

Multi-view foundation model for coronary angiography trained with video-text contrastive learning on 203,808 angiography videos from 28,117 patients across 32,473 studies at the Montreal Heart Institute, externally validated on 4,249 studies from UCSF. Integrates multiple angiographic projections with attention-based pooling for study-level assessment spanning diagnostic, prognostic, and disease-progression tasks: significant-stenosis detection (AUROC 0.888 internal / 0.89 external), stenosis-percentage estimation (MAE 13.6% vs. 19.0% for clinical reports), chronic total occlusion, intracoronary thrombus, and coronary calcification detection. Transfer learning further enables one-year MACE prediction (AUROC 0.79) and LVEF estimation (MAE 7.3%) from the same angiography embeddings, with a mean in-hospital inference time of 4.2 seconds.

AI-driven pipeline for quantitative coronary-stenosis assessment from routine DICOM coronary angiography videos, combining vessel tracking with a video Swin3D transformer trained and validated on 182,418 angiography videos spanning 5 years at the Montreal Heart Institute. Achieves a mean absolute error of 20.15% and a classification AUROC of 0.8294 for stenosis-percentage prediction against cardiologist assessment, with lower inter-rater variability than two expert interventional cardiologists, and can be fine-tuned to quantitative coronary angiography (QCA) data for even lower error (MAE 7.75%).

Multimodal cardiac MRI foundation model that fuses 3D+T cine CMR (short-axis and long-axis views) with tabular patient health records (demographics, metabolic, and lifestyle factors) from 42,000 UK Biobank participants. Two-stage self-supervised pretraining -- masked-image reconstruction, then imaging-tabular contrastive alignment -- produces representations that transfer to whole-heart segmentation, cardiac phenotype/physiological-feature regression, and cardiac/metabolic disease classification within one unified framework.