Open-source, user-guided deep learning tool for coronary artery segmentation from invasive coronary angiography (ICA), designed to improve on traditional quantitative coronary angiography (QCA) edge-detection algorithms that typically require manual correction. Rather than segmenting the whole coronary tree indiscriminately, AngioPy lets the user click a handful of ground-truth points along a specific target vessel (including side branches), and predicts a binary mask for that single artery at the chosen cardiac-cycle time-step. Evaluated against an established QCA system on angiograms from the FAME 2 trial, AngioPy achieved an average F1 score of 0.927 (internal) and 0.924 (external validation), with vessel-diameter and lesion minimal-lumen-diameter measurements showing excellent agreement with QCA (r=0.93-0.96).

Fully automatic pipeline that localizes the heart, segments coronary calcium, and produces an Agatston-style coronary artery calcium score from gated and non-gated chest/cardiac CT. A three-stage 3D CNN performs each step in sequence. Validated across the Framingham, NLST, PROMISE, and ROMICAT-II cohorts, where the resulting calcium score predicted cardiovascular events with hazard ratios up to 4.3. Developed by the Harvard AIM Lab.