Automated deep learning workflow that detects and grades tricuspid regurgitation (TR) severity from full transthoracic echocardiography studies. The pipeline first identifies apical-4-chamber (A4C) video clips with color Doppler across the tricuspid valve from a full echo study, then applies a dedicated R(2+1)D video classifier to grade TR severity. Trained on over 2 million echo videos from 47,312 studies at Cedars-Sinai Medical Center and externally validated at Stanford Healthcare, the model identified color-Doppler A4C views with AUC ≥0.999 and detected clinically significant (moderate-or-severe) TR with AUC 0.951 and severe TR with AUC 0.980. Code and trained model weights are released to support prospective evaluation of AI-assisted TR screening.

The original U-Net baseline segmentation network introduced alongside the CAMUS (Cardiac Acquisitions for Multi-structure Ultrasound Segmentation) dataset, one of the largest fully open-access, expert-annotated 2D echocardiography benchmarks. The network segments the left ventricle endocardium (LVEndo), left ventricle epicardium/myocardium (LVEpi), and left atrium (LA) from apical 2-chamber and 4-chamber echo views at end-diastole (ED) and end-systole (ES). In the original ten-fold cross-validation benchmark comparing U-Net, U-Net++, Stacked Hourglass, Anatomically Constrained Neural Networks, and classical methods, the U-Net variant (18M parameters) achieved the best overall accuracy, reaching Dice scores of 0.939 (ED) / 0.916 (ES) for LVEndo and 0.954 (ED) / 0.945 (ES) for LVEpi, approaching inter-observer variability. A pretrained checkpoint of this baseline U-Net is distributed via the University of Sherbrooke's vitalab CASTOR project as part of a broader library for building anatomically-constrained cardiac segmentation pipelines.

Dual Bayesian ResNet model for heart murmur detection from multi-location phonocardiogram (PCG) recordings, developed for the George B. Moody PhysioNet Challenge 2022. Each patient's PCG recordings are segmented into overlapping log-mel spectrograms, which are passed through two Bayesian ResNet binary classifiers running simultaneously (present vs. unknown-or-absent, and unknown vs. present-or-absent); the two outputs are aggregated into a patient-level present/unknown/absent murmur classification. An optional second-stage XGBoost model integrates the DBRes output with demographic data and hand-crafted signal features. On the Challenge's official hidden test set, DBRes achieved a weighted accuracy of 0.771 for the murmur-detection task, placing 4th among all teams.

Deep learning framework, developed in collaboration with the MONAI community, for automatic segmentation of tricuspid valve leaflets from transthoracic 3D echocardiograms in children with hypoplastic left heart syndrome (HLHS) and other forms of single-ventricle congenital heart disease, integrated into 3D Slicer via MONAILabel for interactive clinical/research use. Addresses a modality (pediatric 3D echocardiography) and population (single-ventricle congenital heart disease) largely absent from adult-focused cardiac AI models.

Predicts cardiac MRI (CMR) tissue-characterization findings -- wall-motion abnormalities and myocardial scar -- directly from standard transthoracic echocardiography videos (A4C/A2C/PLAX views), using a factorized 3D R2+1D convolutional network. Trained and validated on a single-institution cohort of more than 1,400 patients with paired echo and CMR studies within 30 days of each other. Released weights and inference code cover the two binarized outcomes (wall motion, scar); the continuous CMR tissue markers (native T1, T2, ECV) evaluated in the paper are not part of the public release.

Self- and weakly-supervised pipeline for left-ventricle segmentation across the full cardiac cycle in apical-4-chamber echocardiography videos. A video segmentation network (2D super-image or 3D U-Net encoder) is first pretrained with a self-supervised temporal-masking objective on largely unannotated echo frames, then fine-tuned with weak supervision from the sparse end-diastole/end-systole frame labels that most echo datasets provide. Achieves 93.3% Dice on EchoNet-Dynamic, outperforming nnU-Net and non-SSL baselines, and generalizes to the external CAMUS dataset. Developed by the BioMedIA group at MBZUAI.

Video-based deep learning model that grades aortic regurgitation (AR) severity—none/trace, mild, moderate, or severe—from color Doppler echocardiography. View-specific R(2+1)D 3D-CNNs analyze five standard transthoracic views (PLAX, PLAX-AV, A3C, A3C-AV, A5C) and their outputs are combined by a maximum-severity rule at the study level. Trained on ~47,600 color Doppler videos from Cedars-Sinai and externally validated at Stanford Healthcare, reaching AUCs of 0.95 for at-least-moderate AR and 0.97 for severe AR internally. Developed by the Ouyang lab at Cedars-Sinai Medical Center.

Deep learning model for automated phenotyping of mitral stenosis (MS) from echocardiography. Uses video-based R(2+1)D convolutional networks on color Doppler and B-mode views to identify and grade mitral stenosis severity, following the multi-view valvular-assessment approach of the EchoNet family. Trained and validated on large clinical echocardiography cohorts from Kaiser Permanente Northern California with external testing at Stanford Healthcare and Cedars-Sinai. Developed by the Ouyang lab.

CNN-based image classifier that screens 12-lead ECG images for a signature of transthyretin amyloid cardiomyopathy (ATTR-CM), producing a study-level probability score. Trained on a private Yale New Haven Health System cohort of nuclear-imaging-confirmed ATTR-CM cases and matched controls. Used alongside a companion echocardiography model to track pre-clinical ATTR-CM progression years before it would otherwise be confirmed by nuclear amyloid imaging. Developed by Yale's CarDS Lab and distributed as a packaged research-use executable rather than downloadable weights.

EfficientNet-B3 CNN that detects hypertrophic cardiomyopathy directly from images of printed or scanned 12-lead ECGs, rather than from raw digital waveforms, enabling screening from a photo of a paper tracing. Initialized via self-supervised contrastive pretraining on patient identity, then fine-tuned at Yale New Haven Hospital on over 124,000 ECGs from about 67,000 patients, with HCM status confirmed by cardiac MRI or echocardiography. Externally validated on ECG images from MIMIC-IV, Amsterdam UMC, and UK Biobank. Developed by Yale's CarDS Lab.

Two-stage pipeline that segments the left atrium and quantifies atrial scar tissue from 3D late-gadolinium-enhancement cardiac MRI, supporting atrial-fibrillation ablation planning. A Multi-Scale Weight Sharing network first delineates the atrial cavity, then a boundary-patch method segments scar tissue around the detected wall. Developed at Queen Mary University of London for the LAScarQS 2022 MICCAI/STACOM segmentation challenge.