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Multimodal Cardiovascular Risk Profiling from Polysomnography (sleep-ssl)

University of Arizona

Single-lead ECG

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ECG

Multimodal

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Multimodal

General Purpose / Multi-task

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General / Foundation

Regression

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Regression

Hybrid

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Hybrid / Multi-branch

PyTorch

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PyTorch

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Model weights not public. Contact creators for more information.

Self-supervised deep learning model that extracts cardiovascular-risk-relevant patterns from multimodal polysomnography (PSG) signals -- EEG, ECG, and respiratory signals -- without relying on manual sleep-stage annotations. Trained on 4,398 participants, the model derives 'projection scores' by contrasting embeddings from individuals with and without cardiovascular disease (CVD) outcomes. Externally validated in an independent cohort of 1,093 participants, ECG-derived projection scores were predictive of prevalent and incident cardiac conditions (particularly CVD mortality), and combining projection scores with the Framingham Risk Score consistently improved prediction (AUC 0.607-0.965 internally, 0.710-0.807 externally across most outcomes).

memory Specifications

category

Architecture

Hybrid

Self-supervised backbone combining residual and transformer blocks over multimodal (EEG, ECG, respiratory) polysomnography signals, with disease-related "projection scores" derived by contrasting embeddings of CVD-positive vs. CVD-negative individuals in the learned latent space

code

Framework

PyTorch

calendar_month

Added to catalog

2026-08-14

description Publication

Multimodal cardiovascular risk profiling using self-supervised learning of polysomnography open_in_new

He Z, Li H, Yuan G, Killgore WDS, Quan SF, Chen CX, Li A

SLEEP · 2025 · original paper

DOI: 10.1093/sleep/zsaf371

database Training & evaluation data

Independent Polysomnography External Validation Cohort (sleep-ssl)

test

public 1,093 subjects

Sleep Heart Health Study / Wisconsin Sleep Cohort (sleep-ssl training)

train

public 4,398 subjects · USA

science Capabilities & performance

Cardiovascular-disease-related projection scores derived from self-supervised embeddings of multimodal polysomnography (EEG/ECG/respiratory) signals

Regression General Purpose / Multi-task