CardioLab

Multimodal deep-learning framework that estimates and forecasts abnormal laboratory values directly from a 12-lead ECG plus routinely available demographics, biometrics, and vital signs -- reframing dozens of blood tests as binary classification targets predictable from a test that is already fast, non-invasive, and nearly universal in acute care. A structured state-space (S4) encoder processes the raw ECG waveform and is late-fused with an MLP encoder over the tabular metadata; the same architecture is trained both to estimate the closest lab value within 60 minutes of the ECG ('abnormality prediction') and to forecast whether a value will become abnormal 30/60/120 minutes into the future ('abnormality forecasting'). Trained and evaluated on 385,480 linked ECG-lab-value samples from 127,994 MIMIC-IV patients, the model reaches AUROC > 0.7 for 24 distinct lab abnormalities in the prediction setting and 24 in the forecasting setting, spanning cardiac, renal, hematological, metabolic, immunological, and coagulation categories -- with NT-proBNP elevation the best-predicted marker (AUROC 0.90), followed by hemoglobin, albumin, and hematocrit derangements (AUROC > 0.82). Code for dataset construction, training, and evaluation is public under an MIT license; no pretrained model weights are released.