3D nnU-Net Aortic Dissection Pipeline

Fully automatic four-module deep learning pipeline for identifying, segmenting, and Stanford-subtyping aortic dissection (AD) from CT angiography (CTA). A 3D full-resolution nnU-Net first segments the aorta; the segmented boundary is then multi-view projected for AD identification; for AD-positive cases, a second 3D nnU-Net segments the true lumen (TL) and false lumen (FL); finally, a classifier performs Stanford subtyping from multi-view maximum-density projections of the TL/FL. On 386 CTA scans, the pipeline achieved 0.979 accuracy for AD identification, Dice of 0.968 (TL) and 0.971 (FL) for lumen segmentation, and 0.990 accuracy for Stanford subtyping.