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DeepSA (Deep Subtraction Angiography)

Chongqing Medical University (Zeng et al.)

Coronary angiography

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Invasive Coronary & Intracoronary Imaging

General Purpose / Multi-task

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General / Foundation

Coronary artery segmentation / anatomy

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Coronary & Ischemic Disease

Generation

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Generation

Segmentation

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Segmentation & Detection

CNN (2D)

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Convolutional (CNN)

PyTorch

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PyTorch

Self-supervised model that performs single-frame digital-subtraction-angiography-style vessel/background separation directly from a single live (non-subtracted) coronary angiogram frame, then supports fine-tuned coronary vessel segmentation. A U-Net-style network is pretrained via an image-to-image translation objective on 58,128 unannotated angiography DICOM series (3,756 patients), then fine-tuned for vessel segmentation on just 40 expert-annotated frames, reaching a Dice of 0.828 on the held-out fine-tuning set and a new state-of-the-art Dice of 0.755 on the public XCAD benchmark. Intended to help clinicians visualize potential stenosis sites without requiring true two-frame digital subtraction acquisition.

memory Specifications

category

Architecture

CNN (2D)

Self-supervised U-Net trained via an image-to-image translation objective for single-frame vessel/background subtraction, subsequently fine-tuned for supervised coronary vessel segmentation

code

Framework

PyTorch

calendar_month

Added to catalog

2026-08-12

description Publication

Pretrained subtraction and segmentation model for coronary angiograms open_in_new

Yunjie Zeng, Han Liu, Juan Hu, Zhengbo Zhao, Qiang She

Scientific Reports · 2024 · original paper

DOI: 10.1038/s41598-024-71063-5

database Training & evaluation data

public 40 subjects · China

40 coronary angiography images with fine-grained, expert-annotated vessel segmentation masks, used to fine-tune DeepSA for supervised vessel segmentation.

public 3,756 subjects · China

58,128 unannotated coronary angiography DICOM series from 3,756 patients at the Second Affiliated Hospital of Chongqing Medical University, used for self-supervised pretraining of single-frame vessel/background subtraction.

XCAD (public X-ray coronary angiography vessel-segmentation benchmark)

test

Public benchmark of X-ray coronary angiography images with vessel-segmentation ground truth, used by DeepSA as an external, out-of-distribution evaluation set.

science Capabilities & performance

Single-frame digital-subtraction-angiography-style image synthesized directly from one live (non-subtracted) coronary angiogram frame

Generation General Purpose / Multi-task

Binary segmentation of the coronary vessel tree in X-ray coronary angiography frames

Segmentation Coronary artery segmentation / anatomy
0.828 Dice FS-CAD held-out set · internal
0.755 Dice XCAD public benchmark · external